New Releases by Kevin Tong

In the finale to the Arc of a Scythe trilogy, dictators, prophets, and tensions rise. In a world that''s conquered death, will humanity finally be torn asunder by the immortal beings it created? Citra and Rowan have disappeared. Endura is gone. It seems like nothing stands between Scythe Goddard and absolute dominion over the world scythedom. With the silence of the Thunderhead and the reverberations of the Great Resonance still shaking the earth to its core, the question remains: Is there anyone left who can stop him? The answer lies in the Tone, the Toll, and the Thunder.--adapted from publisher''s description.

All living organisms consist of cells that undergo a cell cycle to grow and divide so that the resulting daughter cells are exact replicas of the parent cell. To achieve this feat, a parent cell will first replicate its DNA into two identical copies during S phase of the cell cycle, and then segregate those copies into two daughter cells during anaphase of mitosis. Ensuring that daughter cells receive identical sets of chromosomes requires mechanisms that check for accurate DNA replication, compaction of replicated sister chromatids, and proper segregation of chromosomes. The protein complex termed cohesins identify replicated sister chromatids by tethering them together until anaphase. Additionally, cohesins function in proper chromosome condensation and DNA replication. Using the cohesion maintenance factor Pds5, a component of cohesins, this body of work explores the mechanisms of various cohesin-dependent pathways. These studies reveal that 1) sister chromatid coheison is mediated by a dimeric or oligomeric cohesin complex, 2) cohesin-dependent functions in sister chromatid cohesion and condensation are independently regulated, and 3) Pds5, in combination with Replication Factor C (Elg1-RFC), is required for DNA fork replication progression.