New Releases by Michael Geier

The increasing use of targeted therapy (TT) has resulted in prolonged disease control and survival in many metastatic cancers. In parallel, stereotactic radiotherapy (SRT) is increasingly performed in patients receiving TT to obtain a durable control of resistant metastases, and thereby to prolong the time to disseminated disease progression and switch of systemic therapy. The aims of this study were to analyze the safety and efficacy of SRT combined with TT in metastatic cancer patients and to assess the influence of continuous vs. interrupted TT during metastasis-directed SRT. The data of 454 SRTs in 158 patients from the international multicenter database (TOaSTT) on metastatic cancer patients treated with SRT and concurrent TT (within 30 days) were analyzed using Kaplan-Meier and log rank testing. Toxicity was defined by the CTCAE v4.03 criteria. The median FU was 19.9 mo (range 1-102 mo); 1y OS, PFS and LC were 59%, 24% and 84%, respectively. Median TTS was 25.5 mo (95% CI 11-40). TT was started before SRT in 77% of patients. TT was interrupted during SRT in 44% of patients, with a median interruption of 7 (range 1-42) days. There was no significant difference in OS or PFS whether TT was temporarily interrupted during SRT or not. Any-grade acute and late SRT-related toxicity occurred in 63 (40%) and 52 (33%) patients, respectively. The highest toxicity rates were observed for the combination of SRT and EGFRi or BRAF/MEKi, and any-grade toxicity was significantly increased when EGFRi (p = 0.016) or BRAF/MEKi (p = 0.009) were continued during SRT. Severe (≥grade 3) acute and late SRT-related toxicity were observed in 5 (3%) and 7 (4%) patients, respectively, most frequently in patients treated with EGFRi or BRAF/MEKi and in the intracranial cohort. There was no significant difference in severe toxicity whether TT was interrupted before and after SRT or not. In conclusion, SRT and continuous vs. interrupted TT in metastatic cancer patients did not influence OS or PFS. Overall, severe toxicity of combined treatment was rare; a potentially increased toxicity after SRT and continuous treatment with EGFR inhibitors or BRAF(±MEK) inhibitors requires further evaluation.

Die vorliegende Master-Thesis beschäftigt sich mit den theoretischen Grundlagen, sowie der Konzeption, Beschreibung und Skizzierung eines Augmented Reality Prototypen Systems zur Erweiterung der Realität im sportlichen Trainingsbetrieb am Beispiel Fußball. Die Basis in dieser Arbeit stellen dabei zwei qualitative Methoden dar. Zum einen wurde das Prototypen System mittels der Methodik des Design-Thinkings konzipiert, fortführend näher beschrieben und abschließend noch skizziert. Zum anderen wurde das AR-Prototypen System weiterführend auf Akzeptanzen, Barrieren und eine Realisierbarkeit im angedachten Zielmarkt, durch Lead User aus der definierten Zielgruppe, mittels qualitativer Interviews abgetestet. Der Verfasser erhofft sich durch diese Arbeit einen Mehrwert für die gesamte Zielgruppe, sowie die Grundlage für eine konkrete Entwicklung des aus dieser Arbeit hervorgehenden AR-Prototypen Systems, zu schaffen.****This master's thesis deals with the theoretical basics, as well as the conception, description and sketching of an augmented reality prototype system for the enlargement of the reality in the sportive training enterprise on the example football. The basis of this work is represented by two qualitative methods. On the one hand, the prototype system was designed using the methodology of design thinking, further described in detail and finally outlined. On the other hand, the AR prototype system was further tested for acceptance, barriers and feasibility in the intended target market by lead users from the defined target group, using qualitative interviews. The author hopes that this work will create added value for the whole target group as well as the basis for a concrete development of the AR prototype system resulting from this work.

A Fully Revised Guide to Electronics Troubleshooting and Repair Repair all kinds of electrical products, from modern digital gadgets to analog antiques, with help from this updated book. How to Diagnose and Fix Everything Electronic, Second Edition, offers expert insights, case studies, and step-by-step instruction from a lifelong electronics guru. Discover how to assemble your workbench, use the latest test equipment, zero in on and replace dead components, and handle reassembly. Instructions for specific devices, including stereos, MP3 players, digital cameras, flat-panel TVs, laptops, headsets, and mobile devices are also included in this do-it-yourself guide. Choose the proper tools and set up your workbench Ensure personal safety and use proper eye and ear protection Understand how electrical components work and why they fail Perform preliminary diagnoses based on symptoms Use test equipment, including digital multimeters, ESR meters, frequency counters, and oscilloscopes Interpret block, schematic, and pictorial diagrams Disassemble products and identify sections Analyze circuits, locate faults, and replace dead parts Re-establish connections and reassemble devices.

Master the Art of Electronics Repair In this hands-on guide, a lifelong electronics repair guru shares his tested techniques and invaluable insights. How to Diagnose and Fix Everything Electronic shows you how to repair and extend the life of all kinds of solid-state devices, from modern digital gadgetry to cherished analog products of yesteryear. You'll start by selecting the tools and test equipment you'll need and setting up your workbench. Then, you'll get familiar with components and how they form circuits, stages, and sections of a device. Next, you'll learn how to take a product apart, figure out what's wrong with it, replace components, and reassemble it. Real-world case studies help clarify the topics covered. Tips and tricks for specific devices, such as optical disc players, computers, and video recorders, are also included in this practical resource. Set up a workbench and equip it with tools and test instruments Ensure personal safety and avoid electrical and physical damage to devices Understand electrical units, circuits, and signals Use test equipment, including a digital multimeter, signal generator, frequency counter, and an oscilloscope Repair circuit boards and replace parts Work with components, from capacitors and ICs to transistors and zeners Learn to read block, schematic, and pictorial diagrams Disassemble devices and identify sections and stages Troubleshoot and diagnose to the component level Perform reverse-order reassembly