New Release Books by James Forde

This book explores the different ways in which the early Haitian state was represented in print culture in America and Britain in the early nineteenth century. This study demonstrates that American and British arguments about the most effective forms of governance and political leadership impacted how Haiti’s early leaders were presented to transatlantic audiences. From the end of the Haitian Revolution and the moment that Haitian independence was declared in 1804, conservatives and radical thinkers on both sides of the Atlantic used Haiti and its early leaders as central frames of references in discussions of political legitimacy. Against the backdrop of a vibrant and volatile age of revolutions, the different forms of governance adopted by Jean Jacques Dessalines, Henry Christophe and Jean Pierre Boyer were used by writers, playwrights and caricaturists to either support or call into question the legitimacy of America’s and Britain’s own forms of government.

This work was made at How to Flatten a Mountain, a 12 days residency opportunity presented by PhotoIreland & Cow House Studios, and with the support of OPW. This residency is open to emerging and mid-career visual artists whose artistic practice in whole or part, makes use of digital and/or analogue photographic processes. The workshop facilitators in this edition will be Kim Haughton, Aisling McCoy, and Matthew Thompson, and the colophon of the residency is an exhibition of the works produced, presented during the PhotoIreland Festival at Rathfarnham Castle.

Abstract: The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. However, the giant cell progenitor identity remained unclear. Here, we show that the giant cell-forming potential is a particular trait of monocyte progenitors. Common monocyte progenitors potently produce cytokines in response to mycobacteria and their immune-active molecules. In addition, common monocyte progenitors accumulate cholesterol and lipids, which are prerequisites for giant cell transformation. Inducible monocyte progenitors are so far undescribed circulating common monocyte progenitor descendants with high giant cell-forming potential. Monocyte progenitors are induced in mycobacterial infections and localize to granulomas. Accordingly, they exhibit important immunological functions in mycobacterial infections. Moreover, their signature trait of high cholesterol metabolism may be piggy-backed by mycobacteria to create a permissive niche