New Releases by Ian Andrew

Over three chapters, this thesis studies the colophon at the end of Fourth Kingdoms in BnF Syr. 27, which is divided into several main sections. Chapter 1 provides a transcription of the colophon, analysis of the main paratextual features, and a first-time translation into English. Chapter 2 compares the first main section of the colophon with a similar extant text from Origen, noting that no known extant text matches the material in the colophon. Then, it compares the second major section with Pseudo-Athanasius’s Synopsis Scripturae Sacrae and, to some extent, Epiphanius’s On Weights and Measure, noting where the colophon relies on and is different from these texts. In Chapter 3 the third major section is especially compared with Epiphanius’s On Weights and Measures as it is contained in BL Add. 17148 to demonstrate BnF syr. 27’s reliance upon this text.

In Hippocrasy, two world-leading doctors - rheumatologist and epidemiologist Rachelle Buchbinder and orthopaedic surgeon Ian Harris - reveal the true state of modern medicine and how doctors are letting their patients down. They argue that the benefits of treatments are often wildly overstated and the harms understated. That overtreatment and overdiagnosis are rife. And the medical system is not fit for purpose: designed to deliver health care not health. This powerful expose blows the lid off everything from rampant overdiagnosis and overtreatment (revealing the tests, drugs and treatment that provide no benefit for the patient), to the role of Big Pharma and the inherent problem of a medical system based on treating rather than preventing illness. The book also provides tips to empower patients and solutions to help restructure how medicine is delivered so doctors can live up to their Hippocratic Oath. ''One of the hardest things for a doctor to do...is nothing. This superb book explains how in medicine and surgery, less is often not just more, it''s closer to the oath we''re all supposed to practise by.'' - Norman Swan

The objective of this work was to develop a biophysical model that would elucidate the role of the brain neurofibrillary tangles (NFTs) play in the development of Alzheimer''s disease (AD). AD is a devastating neurodegenerative disease, and this study [the study of Ian] is not only of substantial societal impact, but it will also contribute to the multidisciplinary efforts aimed at early detection, understanding factors behind disease progression and possibly personalized treatment of the disease. AD affects approximately 6.2 million Americans and is expected to grow exponentially by 2050 as the population ages. Those with AD required 15.3 billion hours of care, most of which is unpaid care from family members, and costs, on average, $321,780 per person.Current hypotheses on the mechanism of AD incorporate the combined role of two proteins: beta amyloid plaques and NFTs. They are hypothesized to work together in the amyloid cascade hypothesis to bring about the toxic effects of disease. The tau protein normally stabilizes microtubules in the central nervous system, but its phosphorylation causes destabilization and the formation of tangles. The direct cause of this phosphorylation is unknown, but amyloid plaques are believed to play a role. These tangles disrupt neuron function and synaptic communication. Unable to communicate, these cells die. The tangles propagate via synapticsynaptic connections, resulting in neuronal dysfunction, eventually cell death and thus regional atrophy which follows the pattern of NFTs. Cognitive decline increases as the disease worsens, generally thought to correlate with increasing spread of NFTs. Currently, AD is only able to be definitively diagnosed at autopsy, complicating the understanding of the disease and validation of therapeutic clinical trials. The advent of amyloid- and tau-specific PET tracers in conjunction with other imaging biomarkers has led to a hypothetical model of the progression of AD. However, the mechanism of propagation of disease is still not well defined.Quantitative and qualitative descriptions of the accumulation and advancement of NFTs throughout the cerebrum from both in vitro pathologic staining and in vivo flortaucipir NFT PET imaging characterizes the propagation of NFTs by increasing local intensity and increasing spatial extent. Here we describe a local accumulation connected spread (LACS) model of NFT propagation which naturally encompasses the intensity-extent phenomenon through a reaction-diffusion equation wherein the molecular mechanisms leading to tau accumulation in neurons represents the reaction and the expansion of tau with increasing disease stage along connected white matter trajectories is considered as a diffusion process.We explored three objectives to better understand the utility of the LACS model in predicting future NFT burden as represented by flortaucipir PET. First, we examined confounding factors inherent to flortaucipir PET and their effects on flortaucipir quantitation. Second, we generated a whole brain connectome to model the diffusion process and related harmonics of the connectome to flortaucipir uptake to understand concordance between connectivity and NFT burden. Third, we estimated parameters for LACS using Bayesian inversion to incorporate the uncertainties inherent to flortaucipir quantitation and the LACS model itself and predicted future NFT burden in a clinical trial population. The application of LACS modeling may provide insight into the accumulation and propagation of NFTs as represented by flortaucipir (FTP) PET throughout the cerebrum as well as the development of novel, tailored endpoints for AD therapeutic trials.

International award-winning writer Ian Andrew is a passionate advocate for Indie Authors and their ability to self-publish professionally. His beginner''s guide navigates you through the use of eBook, paperback and hardback Print on Demand suppliers so that you can successfully self-publish your first book with ease. Given his twenty plus years experience as a professional instructor and lecturer, Ian details the steps you need to take in an unhurried, plainly written and often humorous way. Explaining how to use the Kindle Direct Publishing, Draft2Digital, and IngramSpark interfaces, how to expertly use Microsoft(R) Word(R) to format your manuscript and with additional information on ISBNs, Legal Deposit and other fundamentals of self-publishing, this is a must-read for any Indie Authors wishing to turn their book dream into a book reality. 2nd Edition with all new updates on the use of KDP for paperback.

The first book of Ian Irvine''s international bestselling Three Worlds epic fantasy sequence.

The innovative Newcastle Challenging Behaviour Model for dementia care has recently been updated, leading to new advances in the field. This revised second edition guide to assessment and treatment of behaviours that challenge associated with dementia includes these latest developments along with new sections on what have traditionally been considered controversial topics. The new chapters cover issues including: - End of life care - Use of therapeutic dolls - Lies and deception - Physical restraint during personal care - Racism towards care staff With a particular emphasis on non-pharmacological approaches, this book details the range of behaviours common in individuals with dementia, along with the most effective assessment and treatment techniques for health care professionals.

The latest Wright & Tran novel - British weapons in Syria, rogue UK military out to settle scores and hired killers converging on London. Kara Wright needs all her friends about her, yet the most trusted is half a world away.

The horrors and tragedies of the First World War produced some of the finest literature of the century: including Memoirs of an Infantry Officer; Goodbye to All That; the poetry of Wilfred Owen and Edward Thomas; and the novels of Ford Madox Ford. Collectively detailing every campaign and action, together with the emotions and motives of the men on the ground, these ''war books'' are the most important set of sources on the Great War that we have. Through looking at the war poems, memoirs and accounts published after the First World War, Ian Andrew Isherwood addresses the key issues of wartime historiography-patriotism, cowardice, publishers and their motives, readers and their motives, masculinity and propaganda. He also analyses the culture, society and politics of the world left behind. Remembering the Great War is a valuable, fascinating and stirring addition to our knowledge of the experiences of WWI.

Recent revisions of the Newcastle Challenging Behaviour Model have prompted the second edition of this guide to assessing and treating a range of behaviours when caring for older people with dementia. New material includes the use of physical restraint during personal care, lies and deception, end of life issues, and racism towards care staff.

A small book of silly poems and some not so silly verses.

Kara Wright and Tien Tran are back, but this time the women must endure mental stress worse than anything they experienced from combat and, like combat, not everyone makes it home.

Kara Wright and Tien Tran, combat veterans of an elite intelligence unit, now make their living as Private Investigators. Often working the mundane, just occasionally they get to use all their former training. When siblings Zoe and Michael Sterling insist that their middle-aged parents have gone missing, Kara and Tien are at first sceptical and then quickly intrigued; the father, ex-intelligence analyst Chris Sterling, appears to be involved with an elusive Russian thug. Using less than orthodox methods and the services of ex-colleagues with highly specialised talents, Wright & Tran take on the case. But the truth they uncover is far from simple and will shake Zoe and Michael as much as it will challenge Tien and anger Kara. Anger she can ill afford for she is being hunted by others for the killing of a street predator who chose the wrong prey. The only constant in this darkening world is that nothing and no one can be taken at face value.

The gap between the achievement scores of Latino and Black students compared to the scores of White and Asian students has received considerable attention from educators, with little progress made toward closing the gap. This study used growth mindset research to address four destructive learning threats that may contribute to the achievement gap for students in high-minority, low-income schools: negative school culture norms, the Pygmalion effect, stereotype threat, and fixed mindsets. Since the publishing of growth mindset research, leaders and teachers have looked for guidance on harnessing its ability to close achievement gaps in schools. Interventions for removing these threats to learning show promise. For this qualitative participatory action research study, I designed the growth and fixed mindset norms framework for implementation in school cultures. The framework was created to give school leaders a tool for building school culture norms that counteract the learning threats. Seven school leaders participated in three reflection, learning, and planning sessions, which gave them the tools to implement the norms. School leaders were given autonomy to choose the best path toward implementing the framework at their schools. Leaders conducted pre- and post-session observations of school cultures using the framework with the intention of measuring success levels for norm change. I analyzed the leaders'' implementation actions, which revealed drivers and barriers to implementation of the norms. One leader achieved high norm change, while three leaders achieved moderate norm change. Their actions illuminated a set of strategies for implementation. The successful leaders provided professional development and coaching on the norms. However, the most successful leaders provided teachers with targeted coaching on the norms and offered intervention coaching for struggling teachers. The four unsuccessful leaders did not provide their teachers with these same competency-building activities. Instead, they claimed they were stalled in their desire to implement the norms by shared-decision making models. As a result, their schools showed no norm change or their school cultures became more fixed over time. The findings in this study show that norm change is possible with intentional and coordinated action. Based on the experience of the participating leaders, I provide recommendations for leaders seeking to build schoolwide cultures with growth mindset norms.

This book''s hero is Darius Antonopoulos, an artist and apprentice printer who left London in 1605 to visit his ancestral home in Greece. What he found there was to send him on an incredible journey - a quest to discover the Seven Wonders of the World.

This book is a detailed guide to using CBT with older people both with and without cognitive difficulties. Reviewing its use in different settings, it covers both conceptual and practical perspectives, and details everything from causes and initial assessment to case formulation and change techniques.

THE story of how industrial waste was transformed into the only acoustic instrument to be invented in the 20th century is told in Our Time is Now, a collection of essays by nonagenarian writer Cy Grant. That instrument is the steelpan, made from discarded oil drums in Trinidad after the Second World War, whose musicology Grant uses as a platform for a wider examination of the role of music in culture. Pan as Comic Symbol, one of six essays, is in fact part of Grant''s overall critique of western society, expounded more fully in his 2005 book Blackness and the Dreaming Soul in which he examines the West''s alienation from the natural world. The development of steelpan has paralleled that of calypso and carnival, so it is somehow fitting that Grant, a household name in the 1950s as a calypso singer, should be writing about it.

This work makes a case for a West Indian British poetry which at first parallels and later becomes distinct from either of its parent bodies, relying instead on a cross-cultural aesthetic that continues to evolve.