Most Popular Books by Lynn Anderson

Fitness is more than body-mind. It is tri-part; body, mind and spirit. Spiritual Fitness will take you on a body, mind and spiritual journey where fitness and health on all three levels will be the focus. Questions will be asked and thought provoking issues will be presented. If followed carefully you will discover the most abundant thing in the universe; energy and how to use it wisely. There is a formula for success and for mastering your life. You will find it within the pages of Spiritual Fitness. See the website www.doctorlynn.com for the companion Aero*boga DVD fitness program.

Abstract: This study analyzes the relations between returns and earnings and returns and cash flows. The purpose is to determine how accounting information is associated with firm performance (market returns). These relations are studied over both short (one and five years) and long (ten years) measurement intervals. Models with varying degrees of distributional restrictions are employed to determine the nature of these relations over each interval. These are OLS, arctan (nonlinear), and a semiparametric (single index) model. Within each measurement interval, firms are partitioned into quartiles based on the length of the firm''s operating cycle. The operating cycle measures how long it takes a firm to convert cash outflows to cash inflows from operations. It also measures the approximate length of time that it takes for changes in operations to result in changes in firm profitability. Nonlinearities likely occur in the returns-earnings relation in part because of the timing of recognition differences in the accrual system. Information is likely recognized by the market before it is in accounting. This differential in recognition results in different valuation coefficients on different components of accounting earnings. Certain components of earnings may have already been recognized by the market so a lower coefficient results. It is likely that extreme earnings contain a higher proportion of these types of components so nonlinearities result in the tails of the earnings distribution. Since changes in operations for firms with shorter operating cycles likely impact the firm''s profitability more quickly, I expect the returns-earnings relation to become linear more quickly for these firms. I hypothesize and results show that the returns-earnings relation is nonlinear over the shorter measurement intervals and become linear as the measurement interval is lengthened for firms with shorter operating cycles. The returns-cash flows relation is also nonlinear for most operating cycle partitions over shorter windows and approximates linearity for most operating cycle partitions over longer intervals. On average, earnings explain a higher proportion of returns than do cash flows for all measurement intervals. This result is even more pronounced when well-specified models are employed.

Major Histocompatibility Complex (MHC) class I molecules play a crucial role in immune surveillance and contribute substantially to varying levels of resistance to many infectious diseases. MHC class I molecules are expressed on all nucleated cells and serve as ligands for NK cell receptors such as killer cell immunoglobulin-like receptors (KIR) and CD94/NKG2 heterodimeric receptors. Macaques are an important translational research model, but have undergone divergent evolution in many immunogenetic regions of their genome. Macaques have an expanded array of MHC-A and MHC-B genes along with an increased complement of lineage II KIR and NKG2C receptors. This has substantially limited our ability to fully understand regulation of NK cells and comparative immunology in this important pre-clinical model. To provide a more complete foundation for studying NK cell biology, I have conducted a detailed study of rhesus macaque MHC class I molecules and their NK cell receptors. I identified MHC class I ligands for 12 rhesus macaque KIRs of previously unknown specificity that fell into three general categories: interactions with multiple Mamu-Bw4 molecules, interactions with Mamu-AG, or interactions with Mamu-A1*012:01. These findings support overlapping, but nonredundant, patterns of MHC class I ligand recognition that reflects extensive functional diversification of rhesus macaque KIR. Additionally, I showed that N-linked glycosylation at specific sites in the D0 domain of rhesus KIR molecules play a role in modulating surface expression and contribute to ligand specificity. Finally, I established that Mamu-E allotypes are differentially stabilized by polymorphic MHC class I leader-derived peptides and that CD94/NKG2 recognition and response is Mamu-E/peptide-dependent. This study suggests that availability of specific leader peptides for presentation by Mamu-E could lower the threshold for NK cell activation by decreasing or interrupting inhibitory signaling. This dissertation serves as a valuable resource for immunologists providing new insights into NK cell responses in rhesus macaques as a pre-clinical model. It lays the foundation for further characterization on how MHC class I peptide presentation modulates NK cell responses and can help discern the intricacies of innate immune responses to infectious disease.

Background. Understanding differences in genital injuries after non-consensual and consensual intercourse is an important element of prosecuting sexual assault cases.