Best Selling Books by Sally Lee

A world without telephones? Impossible for most young readers to imagine. Find out how you can thank inventor Alexander Graham Bell for every ringtone! Filled with facts and photos, Bell''s story highlights the scientific process he followed, failures and all, from identifying a problem to getting his communication technology into the hands of users.

Find out the facts on favorite holidays and their early traditions. Children can compare how the holiday they celebrate today is different from the past.

Yosef, Yolanda and Yara are three yaks in the Yunnan who are traded to the Yukon for three Yamahas. The Yukon uses the yak''s art of yodeling to boost tourist trade. Number 25 in a series of ABC alliterative stories, "Yukon''s Yodeling Yaks" emphasizes each letter "y" or "Y" with a bold font. Children will enjoy the fun story while learning the many uses of the letter "Y" and finding the hidden letter in each picture.

The intrepid travellers ventured once more into the world, this time to the Kingdom of Morocco; the land of crowded souks, soaring mosques, and snow-capped mountains overlooking the dusty deserts. They have sampled Moroccan cuisine, seen the local craftsmen, and wondered at the intricate geometric tiles adorning riads and palaces. Once experienced, all it takes is the smell of the intense spice ras el hanout wafting across the breeze to instantly transport the travellers across time and space to this ancient North African kingdom.

This is a story about child sexual abuse. It is told through the eyes of a pink stuffed bunny. The story was created to help children deal with this type of abuse and the steps they can take to overcome the fear, anger, shame and remorse that comes along with sexual abuse. It is also a good tool for parents, teachers, and professionals who are looking for tools to help children deal with this type of abuse.

Wilbur Wolf worries when the winter wind whistles wildly through the willows in the Wyoming wilderness. Number 23 in a series of ABC alliterative stories, "Wilbur Wolf" emphasizes each letter "w" or "W" with a bold font. Children will enjoy the fun story while learning the many uses of the letter "W" and finding the hidden letter in each picture.

From the potty to the playground, celebrate the wonderful things your two-year-old can do! Sturdy and sure-footed, your child is able to tackle new challenges every day, from physical feats such as tumbling, hopping, and jumping to creative tasks such as painting and music-making. This inviting, informative book is full of inspiring photographs of kids mastering exciting everyday activities-from using the potty or dressing to riding a tricycle and doing gymnastics-with advice on how to help children enhance their coordination. Interactive elements throughout the book-a drum to tap, a shirt to zip-give your child an opportunity to try out his new talents. Ages 2-3

Give kids the confidence of knowing how to stay safe. Easy to follow safety rules and nonthreatening text ease the fears and confusion that can arise from everyday situations.

"The use of assisted reproductive technology (ART) overlaps with crucial dynamic DNA methylation waves taking place during gametogenesis and embryonic development. A number of studies have shown that ART procedures are associated with alterations in embryo development and epigenetic marks. Folic acid supplements have been proposed to be beneficial in preventing embryonic and epigenetic defects in normal and ART-conceived pregnancies, but further dose and mechanistic studies are still required. The goals of the thesis were to use a mouse model to: 1) examine effects of diets supplemented with different levels of folic acid on embryonic development in naturally cycling outbred CF1 mice often used as controls in ART experiments, 2) examine effects of folic acid supplemented diets on the methylation of two imprinted and one non-imprinted gene in the context of ART, and 3) attempt to improve embryo culture conditions by the addition of the growth factor granulocyte-macrophage colony stimulating factor (GM-CSF) to prevent negative impacts of ART not corrected with folic acid. For the first goal, naturally mating mice were fed a control diet containing the daily required intake (DRI) of folic acid for mice (CD) or a moderate dose folic acid supplemented diet containing 4-fold the DRI (4FASD). Embryos and placentas were collected at mid-gestation. Both CD and 4FASD groups showed similar rates of embryonic abnormalities, 4.8% and 4.6% respectively. Pregnancy outcomes between the females on CD or 4FASD were not significantly different. For the second goal, females were exposed to three different folic acid diets (CD, 4FASD, 10FASD), ART was performed, and placentas from female embryos were selected for DNA methylation analysis of a non-imprinted gene, Casz1, and two imprinted genes, Nnat and Gnas. DNA methylation of Casz1 was not affected by ART or either dose of folic acid supplementation. DNA methylation of Nnat was not affected by ART or folic acid supplementation, however the increase in DNA methylation variance due to ART showed evidence of correction with both doses of folic acid supplementation. For Gnas, ART resulted in a decrease in mean DNA methylation and an increase in DNA methylation variance for both regions analyzed, and both changes were partially corrected by the 4FASD. For the third goal, an ART protocol was designed to combine both folic acid supplementation of mothers and GM-CSF in the embryo culture medium. Adjusting the hormone doses to the weight of the mice for the superovulation process increased the number of oocytes ovulated. Washing the mineral oil increased both the in vitro fertilization (IVF) and in vitro development (IVD) rates. The third goal, however, was not further pursued due to poor in vivo development following embryo transfer attributed to issues with the mineral oil. Taken together, this study shows that the CD diet is sufficient for normal development of offspring in naturally cycling CF1 mice, ART affects imprinted and non-imprinted genes differently, and mouse ART protocols can often require optimization. The study provides further evidence that moderate folic acid supplementation, similar to the doses used in human pregnancies, can only partially correct altered DNA methylation associated with ART, suggesting that further efforts are required to improve factors such as embryo culture conditions, including pursuing the use of promising growth factors such as GM-CSF"--

Discusses the uses of pesticides, the dangers they may pose to our food supply, and governmental restrictions imposed on those considered harmful.

Examines different types of nutrients and their effects on the body and discusses malnutrition, vitamin deficiencies, and other conditions which may occur if proper eating habits are not maintained.

A discussion of hurricanes, their formation and structure, forecasting, and safety. Includes some related science projects.