New Releases by Frank Cho

Ten warrior women enter a fight to the death on a dangerous and exotic planet. The last one standing will be crowned Queen of the Galaxy. The Hunger Games meets Wonder Woman! When the Queen of the Galaxy suddenly disappears, ten hard-as-nails women face off in an ancient contest to claim her throne. To win the challenge each contestant must survive the hazards of the planet’s harsh landscape, the ferocious predators on and below its surface, and their fellow contestants. There are no limits in this high-stakes contest, especially when we learn one of the competitors is an infiltrator who has her eye on a bigger prize.

Sur différentes planètes, chaque concurrente doit survivre aux aléas de la nature rude et impitoyable des mondes où elles sont téléportées. Elles font face à de féroces prédateurs, ainsi qu''aux autres concurrentes. Mais l''une des candidates est infiltrée avec pour but de gagner, par tous les moyens. Que veut-elle vraiment?

Ten hard-as-nails women face off in an ancient contest of champions where the winner truly takes all: the title of “Queen of the Galaxy.” To win the challenge each contestant must survive the hazards of the planet’s harsh landscape, the ferocious predators on and below its surface, and their fellow contestants. This edition of the contest has a twist: one of the contestants is an infiltrator who has her eye on something bigger than the prize. Who is she and what does she really want?

Ten hard-as-nails women face off in an ancient contest of champions where the winner truly takes all: the title of “Queen of the Galaxy.” To win the challenge each contestant must survive the hazards of the planet’s harsh landscape, the ferocious predators on and below its surface, and their fellow contestants. This edition of the contest has a twist: one of the contestants is an infiltrator who has her eye on something bigger than the prize. Who is she and what does she really want? In this concluding issue the secrets are revealed…and the empire will never be the same!

Ten hard-as-nails women face off in an ancient contest of champions where the winner truly takes all: the title of “Queen of the Galaxy.” To win the challenge each contestant must survive the hazards of the planet’s harsh landscape, the ferocious predators on and below its surface, and their fellow contestants. This edition of the contest has a twist: one of the contestants is an infiltrator who has her eye on something bigger than the prize. Who is she and what does she really want?

Ten hard-as-nails women face off in an ancient contest of champions where the winner truly takes all: the title of “Queen of the Galaxy.” To win the challenge each contestant must survive the hazards of the planet’s harsh landscape, the ferocious predators on and below its surface, and their fellow contestants. This edition of the contest has a twist: one of the contestants is an infiltrator who has her eye on something bigger than the prize. Who is she and what does she really want?

Collects Savage Wolverine (2013) #1-5. Wolverine awakens to find himself in the Savage Land — and labeled public enemy number one! With no memory of how he got there and Shanna the She-Devil his only ally, Logan must unravel the mystery of the Savage Land before it kills him! The ferocious duo venture into the depths of the Forbidden Island, where they face a brutal gauntlet of battles with the island natives, wild dinosaurs, giant apes and a deadly threat from another world. When another hero crash-lands on the island, he just might turn the tide of the battle — but is he friend or foe? Featuring guest appearances by Amadeus Cho, Man-Thing and the Incredible Hulk!

This thesis presents engineered molecular tools that have been developed for detecting, mapping, and manipulating both intracellular protein-protein and organelle-organelle interactions as well as intercellular cell-cell interactions. The first half of this thesis discusses work on the development and application of a new split proximity labeling enzyme for proteomic mapping with high spatial specificity. Most of the thousands of proteins that comprise a human cell have specific subcellular localization patterns essential for their function. Proximity labeling is a method for mapping the localization of endogenous cellular proteins on a proteome-wide scale. Proximity labeling catalyzed by promiscuous enzymes such as TurboID have enabled the proteomic analysis of subcellular regions difficult or impossible to access by conventional fractionation-based approaches. Yet some cellular regions, such as organelle contact sites, remain out of reach for current proximity labeling methods. To address this limitation, we split the enzyme TurboID into two inactive fragments that recombine when driven together by a protein-protein interaction or membrane-membrane apposition. We targeted split-TurboID to the endoplasmic reticulum (ER) and outer mitochondrial membranes for proteomic mapping of ER-mitochondria contacts. At ER-mitochondria contact sites, reconstituted TurboID catalyzed spatially-restricted biotinylation, enabling the enrichment and identification of u003e 100 endogenous proteins, including many not previously linked to ER-mitochondria contacts, demonstrating the utility of applying split-TurboID for proteomic mapping in previously inaccessible subcellular regions. The second half of this thesis discusses work on developing synthetic molecular circuits that detect cell-cell contacts and either activate a transcription factor or toxin in response. Technologies for detecting cell-cell contacts are powerful tools for studying a wide range of biological processes, from neuronal signaling to cancer-immune interactions within the tumor microenvironment. In Chapter 3, we report TRACC, a GPCR-based transcriptional recorder of cellular contacts, which converts contact events into stable transgene expression. We incorporate light gating using the LOV domain, which provides user-defined temporal control of tool activation and reduces background. We show that TRACC activation is specific and sensitive in mammalian cell culture and that it can be applied for detecting interactions between neurons and glioma cells. In Chapter 4, we design a molecular tool that incorporates a split tetanus neurotoxin pair, in which cell-cell interactions drive the reconstitution of the toxin, enabling cleavage of endogenous SNARE proteins for synaptic silencing. We develop and optimize a split tetanus pair that is only active when driven together by a protein-protein interaction. We also optimized gain-of-signal assays for detecting reconstituted tetanus activity in both HEK293T and primary neuron cultures. With additional optimization and development, this neurotoxin-based tool may be used to systematically correlate defined synaptic connections to behavioral phenotypes, enabling a wide range of potential applications in neuroscience.

Dynamite proudly presents Frank Cho''s Jungle Girl! Overseen by co-writer and artist Frank Cho and infused the issue with everything Cho fans want to see — beautiful women, thrilling adventures, and, of course, dinosaurs — Jungle Girl also features Co-writer Doug Murray (Red Sonja: Queen of the Frozen Wastes, The ''Nam) who''s along for the ride, as is series artist Adriano Batista (New Battlestar Galactica: Zarek, Red Sonja) as they bring the Jungle Girl to life! This Complete Omnibus features all three “Seasons” of the Jungle Girl series, collected for the first time in one book! Jana the Jungle Girl lives in a strange land – a land filled with dinosaurs, prehistoric men, and much, much more! When a group of intruders finds themselves in need, Jana races to save them, kicking off a chain of events that, with each new chapter, reveals more clues about the nature of Jana, and of the island itself!

Kicking off the newest series of DC Collectibles’ famous DC Cover Girls line is Batgirl, designed by popular cover artist Frank Cho. Cho’s clever take on Barbara Gordon gives a touch of humor to the piece. Any fan of Cho’s covers and art will not want to miss this statue, which introduces him as the new artist for the line.

Arthurian legend is alive and well in the modern world, including mythical creatures, fantastical locales, and the one true sword of the king, Excalibur. But when the evil Merlin returns to lay claim to the impossible weapon, only one man can stand in his way—the immortal Thomas Skybourne. Written and illustrated by industry legend Frank Cho (Liberty Meadows, Savage Wolverine), Skybourne is a thrilling blend of fantasy and espionage action that updates the legends of King Arthur for a modern-day reader.

Oversized final issue! The final battle over the fate of Excalibur begins, with Skybourne outmanned and outgunned by Merlin and his supernatural forces. Will the magical weapons of the Mountain Top Foundation be enough to slay the beasts?

In our final issue, Sonja faces off for the last time with the Ice Queen and her army of Neanderthals and Yeti''s, but will the fiery warrior woman prevail against a witch whose blood flows like ice? This month, we present a final series of fabulous cover art from series cover artist and story teller Frank Cho, Stjepan Sejic and interior artist Homs!

The Lost World is doomed! When a tear in the dimensional fabric opens over the forbidden God Mountain, the brave and cunning Jana must rescue her friends Togg and Mike Mize from flaming debris, stampeding dinosaurs, and bloodthirsty tribesmen. Can the intrepid Jungle Girl overcome the chaos caused by the fearsome otherworldly deities known as The Old Ones? Her only salvation, a powerful artifact of alien origin, resides within the Temple of the Dirt People... a journey that will not only lead Jana to horrors undreamt, but also to a terrible revelation about the man she loves most: her father! Acclaimed storyteller Frank Cho (Savage Wolverine, Liberty Meadows) returns to Jungle Girl for its epic third act, co-written by Doug Murray (The ''Nam) and featuring artwork by Jack Jadson (The Savage Hawkman)!

The God Mountain is almost gone, revealing the sleeping behemoth that, when awakened, will destroy the Lost World and all its inhabitants There is only one way to stop it - an ancient device hidden in a temple deep in the forest, although it is missing a vital part. When Jana and Togg locate the piece, it''s up to them to get it to Jana''s father at the temple. Can they do it in time? Can they save the world? And if so, what will it cost them?

The beginning of the End! Creatures from the hovering flying saucer (you''d better check out issue #1 to see where this started!) begin to break up the God Mountain. If they free the dreaming creature inside, the world will be destroyed! Jana and her friends have to fight their way through the Dirt People and past one of their hated and feared Dream Walkers to get to the caverns that holds a piece of an ancient weapon-one that might be able to stop the Aliens from achieving their goal. There''s only one problem-to get the item they need, Jana will have to fight giant blood worms, Gigantopithicenes, and the Dream Walker himself!

"Frank Cho, the acclaimed creator of Liberty Meadows, shares his secrets to drawing the lovely women he is renowned for. His exquisite line and masterful brushstrokes are explored to give the beginning artist, along with the most advanced professional, all the tools and knowledge needed to draw beautiful women." --

Dynamite''s Smash Red Sonja mini-series from creators Frank Cho, Doug Murray and Homs is collected in one deluxe hardcover! Savage Red Sonja: Queen of the Frozen Wastes delivers and action packed story and incredibly art as Sonja battles the beautiful and deadly Ice Queen and her army of Yeti warriors! This collection features all four issues of the series, a complete cover gallery featuring Frank Cho''s incredible covers and more!

The powerhouse creative team of Mark Millar and Terry Dodson bring readers a hyper-realistic, action-packed look at Spider-Man - as they''ve never seen him before! A mysterious villain has discovered Spider-Man''s secret identity... and is using the information to slowly destroy everything and everyone that Peter Parker cares about. But how far will Spider-Man go to protect the people he loves? Is he willing to cross a boundary we thought we''d never see him cross? Featuring Spider-Man''s most fearsome foes and avenging allies!

Life and love in Liberty Meadows, animal sanctuary, where anything and everything can happen. This is the second collection book of the award-winning comic book series Liberty Meadows. This volume collects issues 10 through 18 of the wildly popular Liberty Meadows comic book. All the comic strips are completely remastered and uncensored. With cover art gallery, extensive sketch and illustration section, plus a complete, never-before-published Liberty Meadows short story.

A mysterious villain has discovered Spider-Man''s identity and is using the information to destroy everything that Peter Parker cares about.

She''s bold, she''s beautiful, and she''s your best hope of escaping the raptors nipping at your heels. She''s Shanna, the She Devil! Award-winning creator Frank Cho brings you Marvel''s bodacious jungle girl as you''ve never seen her before: Reborn from Nazi science gone mad to battle her genetic destiny on an island full of prehistoric horrors. Shanna has never looked this good...or acted this bad!

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