New Releases by James D. Watson

The Watson family in New Zealand.

前版に比べ、新たに2章分を追加しながら、全般にわたってアップデート。最先端の関連情報紹介に加え、新たに章末問題を掲載。

A descoberta da estrutura do DNA em 1953 representa um dos maiores avanços científicos da biologia. James D. Watson, um dos cientistas responsáveis pela descoberta, foi posteriormente reconhecido com o Prêmio Nobel por esta notável contribuição à ciência. Outra importante contribuição de Watson foi este livro, Biologia molecular do gene, que apresenta não apenas as bases intelectuais que ajudaram a moldar a biologia molecular no século passado, mas também toda a evolução do conhecimento alcançada desde então.

On the fiftieth anniversary of Watson and Crick receiving the Nobel Prize, a freshly annotated and illustrated edition of The Double Helix provides new insights into a scientific revolution. Published to mark the fiftieth anniversary of the Nobel Prize for Watson and Crick’s discovery of the structure of DNA, an annotated and illustrated edition of this classic book gives new insights into the personal relationships between James Watson, Frances Crick, Maurice Wilkins, and Rosalind Franklin, and the making of a scientific revolution.

6. Aufl. bezieht sich auf die engl. Orig.-Ausg.

Fifty years ago, James D. Watson, then just twentyfour, helped launch the greatest ongoing scientific quest of our time. Now, with unique authority and sweeping vision, he gives us the first full account of the genetic revolution—from Mendel’s garden to the double helix to the sequencing of the human genome and beyond. Watson’s lively, panoramic narrative begins with the fanciful speculations of the ancients as to why “like begets like” before skipping ahead to 1866, when an Austrian monk named Gregor Mendel first deduced the basic laws of inheritance. But genetics as we recognize it today—with its capacity, both thrilling and sobering, to manipulate the very essence of living things—came into being only with the rise of molecular investigations culminating in the breakthrough discovery of the structure of DNA, for which Watson shared a Nobel prize in 1962. In the DNA molecule’s graceful curves was the key to a whole new science. Having shown that the secret of life is chemical, modern genetics has set mankind off on a journey unimaginable just a few decades ago. Watson provides the general reader with clear explanations of molecular processes and emerging technologies. He shows us how DNA continues to alter our understanding of human origins, and of our identities as groups and as individuals. And with the insight of one who has remained close to every advance in research since the double helix, he reveals how genetics has unleashed a wealth of possibilities to alter the human condition—from genetically modified foods to genetically modified babies—and transformed itself from a domain of pure research into one of big business as well. It is a sometimes topsy-turvy world full of great minds and great egos, driven by ambitions to improve the human condition as well as to improve investment portfolios, a world vividly captured in these pages. Facing a future of choices and social and ethical implications of which we dare not remain uninformed, we could have no better guide than James Watson, who leads us with the same bravura storytelling that made The Double Helix one of the most successful books on science ever published. Infused with a scientist’s awe at nature’s marvels and a humanist’s profound sympathies, DNA is destined to become the classic telling of the defining scientific saga of our age.

Du gène de l''immortalité (des cellules souches embryonnaires) aux gènes dont les mutations sont responsables de pathologies diverses en passant par l''appétit, le langage, etc., la liste de nouveaux gènes mis en évidence, ces dernières années, n''en finit pas. Le lien entre les gènes et les caractères qu''ils gouvernent constitue le coeur de la biologie moléculaire. Les applications et les retombées sociétales de ces connaissances rendent de plus en plus nécessaire la compréhension de cette discipline. Ecrit, dans un style clair et accessible, par de grands spécialistes mondiaux de biologie moléculaire dont le Prix Nobel, découvreur de la double hélice de l''ADN, James Watson, ce livre en intègre les principaux aspects : les propriétés physicochimiques et les bases structurales des acides nucléiques et des protéines ; les mécanismes de la maintenance et de l''expression du génome ; les mécanismes de régulation ; les méthodes. Par ailleurs, des approfondissements (théoriques ou expérimentaux) et des applications en clinique humaine sont proposés sur des domaines à la pointe du progrès. Enfin, cet ouvrage se distingue aussi par la large place donnée à l''histoire de cette discipline. La compréhension et l''intégration des connaissances sont facilitées grâce à : des schémas clairs et bien légendés, accompagnés d''une abondante iconographie ; des encadrés " Pour aller plus loin ", " Applications en clinique humaine ", " Expériences clés ", " Techniques " qui aiguisent l''intérêt du lecteur ; un glossaire-dictionnaire français-anglais comprenant plus de 700 définitions. Cet ouvrage, qui a bénéficié d''une traduction-actualisation de qualité grâce à une équipe pédagogique hautement qualifiée et spécialisée, constitue un manuel d''initiation parfaitement adapté pour accompagner l''étudiant dès les premières années de son cursus. Il comblera également les attentes de tous les étudiants de 3e cycle et des scientifiques à la recherche d''un ouvrage de synthèse récent qui comprend les dernières découvertes : par exemple, dans les nouveaux chapitres sur les ARN régulateurs, sur l''analyse du génome et la biologie des systèmes. Il constituera aussi un support actualisé pour les enseignants.

James D. Watson looks back on his extraordinary and varied career - from its beginnings as a schoolboy in Chicago''s South Side to the day he left Harvard almost 50 years later, world-renowned as the co-discoverer of DNA - and considersthe lessons he has learnt along the way. The result is both anengagingly eccentric memoir and an insightful compendiumof lessons in life for aspiring scientists. Avoid Boring People, is a quirky, original, wise, and infuriatingly un-put-downable blend of candid anecdotes and revealing insights into the life of one of the greatest scientists of the 20th century.

Recombinant DNA, Third Edition, is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics. The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.

''Biologia molecular do gene'' explica o que são os genes e como eles funcionam. Sua característica principal é concentrar-se em princípios e conceitos. Além disso, o tema é ilustrado com experimentos descritos principalmente em quadros.

In the years following his and Francis Crick’s towering discovery of DNA, James Watson was obsessed with finding two things: RNA and a wife. Genes, Girls, and Gamow is the marvelous chronicle of those pursuits. Watson effortlessly glides between his heartbreaking and sometimes hilarious debacles in the field of love and his heady inquiries in the field of science. He also reflects with touching candor on some of science’s other titans, from fellow Nobelists Linus Pauling and the incorrigible Richard Feynman to Russian physicist George Gamow, who loved whiskey, limericks, and card tricks as much as he did molecules and genes. What emerges is a refreshingly human portrait of a group of geniuses and a candid, often surprising account of how science is done.

本书是作者的自传,是他关于DNA突破性发现所产生的惊人后果的报告,全书深刻揭示了伟大的科学是如何完成的,又深刻剖析了这位青年男子的勃勃雄心。

In 1953 Watson and Crick discovered the double helical structure of DNA and Watson''s personal account of the discovery, The Double Helix, was published in 1968. Genes, Girls and Gamow is also autobiographical, covering the period from when The Double Helix ends, in 1953, to a few years later, and ending with a Postscript bringing the story up to date. Here is Watson adjusting to new-found fame, carrying out tantalizing experiments on the role of RNA in biology, and falling in love. The book is enlivened with copies of handwritten letters from the larger than life character George Gamow, who had made significant contributions to physics but became intrigued by genes, RNA and the elusive genetic code. This is a tale of heartbreak, scientific excitement and ambition, laced with travelogue and ''50s atmosphere.

In 1953, two young and unknown scientists, James Watson and Francis Crick, sparked a worldwide revolution with their discovery of the molecular composition of DNA. In this collection of outspoken and topical essays, speeches and reports, Watson offers his unique insight into the advance of molecular genetics, the prospect of curing cancer over the next decade, how human genetic knowledge is likely to be used, particularly in relation to cloning and genetically modified food, as well as shedding light on his early life and career.

[內容簡介]一九五三年詹姆士.華生與法蘭西斯.克里克(Francis Crick)發現了DNA的分子組成是由兩條長鏈互相纏繞而形成的雙螺旋.這項發現讓科學界瞭解遺傳密碼可經轉譯合成蛋白質進而使我們擁有改造生物遺傳特性的能力瞭解如癌症等疾病是由於基因錯誤所產生也奠定複製動植物的技術及生物技術產業的基礎開啓人類基因庫的解讀開啓基因治療的新領域.本書是華生的評述及演講首度彙集成冊從他十五歲以天才兒童的身分進入芝加哥大學到進入印第安那大學研究噬菌體到劍橋與說多偉大科學家切磋到成為冷泉港實驗室所長這一路來所面臨的挑戰,責難與毀譽參半他都直言不諱地瘦表他對學院,科學界,政府與民間團體的看法本書可以說是華生愛上DNA以及一輩子研究DNA的心路歷程.

By identifying the structure of DNA, Francis Crick and James Watson revolutionized biochemistry and won a Nobel Prize. All the time Watson was only twenty-four, a young zoologist hungry to make his mark. His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of sciences'' greatest unsolved mysteries gives a dazzlingly clear picture of a world of scientists with great gifts, very human ambitions, and bitter rivalries. With humility unspoiled by false modesty, Watson relates his and Crick''s desperate efforts to beat Linus Pauling to the identification of the basic building block of life.

Portions of this book were first published in The Atlantic monthly.